| Dean Gooderham Acheson | Lisbon | Attended 9th Session of the North Atlantic Council. | February 20–26, 1952 |
| David Dean Rusk | Lisbon | Discussed extension of U.S. base rights in the Azores. | June 27–28, 1962 |
| David Dean Rusk | Lisbon | Met with Premier Caetano and Foreign Minister Franco Nogueira. | November 18–19, 1968 |
| William Pierce Rogers | Lisbon | Met with Prime Minister Caetano and senior Portuguese officials. Amended an air
transport agreement. | May 29–31, 1970 |
| William Pierce Rogers | Lisbon | Attended NATO Ministerial Meeting. | June 1–6, 1971 |
| William Pierce Rogers | Terceira Island (Azores) | Accoompanied President Nixon to meeting with French President Pompidou and
Portuguese Prime Minister Caetano. | December 12–14, 1971 |
| Henry A. (Heinz Alfred) Kissinger | Lisbon | Official visit. Discussed bilateral relations with senior officials. | December 17–18, 1973 |
| Cyrus Roberts Vance | Lisbon | Signed Lajes Base Agreement. | June 19, 1979 |
| Alexander Meigs Haig | Lisbon | Met with Prime Minister Pinto and senior Portuguese officials. | February 10–11, 1982 |
| George Pratt Shultz | Lisbon | Signed a new agreement relating to economic and military assistance. | December 12–13, 1983 |
| George Pratt Shultz | Lisbon | Accompanied President Reagan on a State visit. | May 8–10, 1985 |
| George Pratt Shultz | Lisbon | Attended NATO Ministerial Meeting. | June 6–7, 1985 |
| James Addison Baker | Lisbon | Met with Prime Minister Cavaco Silva and Foreign Minister Pinheiro. | February 15, 1989 |
| James Addison Baker | Lisbon | Witnessed the signing of the Angola Peace Accords. | May 31–June 1, 1991 |
| James Addison Baker | Lisbon | Attended Conference on Assistance to the New Independent States. Signed protocol
making Russia, Belarus, Kazakhstan and Ukraine parties to the START Treaty. | May 23–24, 1992 |
| Warren Minor Christopher | Lisbon | Signed Agreement on Cooperation and Defense. | June 1, 1995 |
| Madeleine Korbel Albright | Sintra | Attended NATO Ministerial Meeting, the inaugural meeting of the Euro-Atlantic
Partnership Council, and a meeting of the Bosnian Peace Implementation Council. Also met
with the Co-Presidents of Bosnia. | May 29–30, 1997 |
| Madeleine Korbel Albright | Lisbon | Attended U.S.-European Union Ministerial meeting. | March 4–5, 2000 |
| Madeleine Korbel Albright | Lisbon | Accompanied President Clinton to the U.S.-EU Summit Meeting and to a meeting with
Israeli Prime Minister Barak. | May 30–June 1, 2000 |
| Condoleezza Rice | Lisbon | Attended a Quartet Principals’ meeting. | July 19–20, 2007 |
| Condoleezza Rice | Lisbon | Met with Foreign Minister Amado. | September 4–5, 2008 |
| Hillary Rodham Clinton | Lisbon | Attended the NATO and U.S.-European Union Summits, the NATO-Russia Summit, and the
International Security Assistance Force Summit. | November 18–20, 2010 |
| Michael R. Pompeo | Lisbon | Met with Prime Minister António Costa and Foreign Minister Augusto Santos
Silva. | December 4–5, 2019 |
