| John Foster Dulles | Karachi | Met with Prime Minister Ali and senior Pakistani officials. | May 22–25, 1953 |
| John Foster Dulles | Karachi | Attended Second SEATO Council Meeting. | March 5–9, 1956 |
| David Dean Rusk | Karachi | Attended CENTO Ministerial Meeting. | April 29–May 2, 1963 |
| William Pierce Rogers | Lahore | Met with President Yahya and senior Pakistani officials. | May 24–25, 1969 |
| Henry A. (Heinz Alfred) Kissinger | Islamabad | Met with Prime Minister Bhutto and senior Pakistani officials. | November 10, 1973 |
| Henry A. (Heinz Alfred) Kissinger | Rawalpindi | Met with Prime Minister Bhutto. | October 31–November 1, 1974 |
| Henry A. (Heinz Alfred) Kissinger | Lahore | Met with Prime Minister Bhutto. | August 8–9, 1976 |
| George Pratt Shultz | Islamabad, Peshawar | Met with President Zia and Foreign Minister Yaqub Khan. Visited an Afghan refugee
camp. | July 2–4, 1983 |
| George Pratt Shultz | Islamabad | Attended the funeral of President Zia. | August 19–20, 1988 |
| Madeleine Korbel Albright | Islamabad, Peshawar | Met with Prime Minister Sharif and visited an Afghan refugee camp. | November 17–18, 1997 |
| Madeleine Korbel Albright | Islamabad | Accompanied President Clinton to meetings with President Musharraf and senior
officials. | March 25, 2000 |
| Colin Luther Powell | Islamabad | Discussed cooperation against terrorism with President Musharraf and senior
officials. | October 15–16, 2001 |
| Colin Luther Powell | Islamabad | Met with President Musharraf and senior officials. Returned to Pakistan after
visiting Afghanistan. | January 15–17, 2002 |
| Colin Luther Powell | Islamabad | Met with President Musharraf and senior officials. | July 28, 2002 |
| Colin Luther Powell | Islamabad | Met with President Musharraf and Foreign Minister Kasuri. | March 17–18, 2004 |
| Condoleezza Rice | Islamabad | Met with President Musharraf and senior Pakistani officials. | March 16–18, 2005 |
| Condoleezza Rice | Islamabad | Met with President Musharraf and Prime Minister Aziz. Discussed disaster
relief. | October 12, 2005 |
| Condoleezza Rice | Islamabad | Accompanied President Bush. | March 3–4, 2006 |
| Condoleezza Rice | Islamabad | Met with President Musharraf and Foreign Minister Kasuri. | June 27–28, 2006 |
| Condoleezza Rice | Islamabad | Met with President Zadari and senior officials. | December 4, 2008 |
| Hillary Rodham Clinton | Islamabad, Lahore | Met with Foreign Minister Qureshi. Announced several assistance programs. | October 28–30, 2009 |
| Hillary Rodham Clinton | Islamabad | Met with President Zardari, Prime Minister Gillani and Foreign Minister Qureshi.
Attended a Strategic Dialogue meeting and announced a series of aid agreements. Promoted
a trade agreement between Pakistan and Afghanistan. | July 18–19, 2010 |
| Hillary Rodham Clinton | Islamabad | Met with President Zardari and Pakistani government and military leaders. | May 27, 2011 |
| Hillary Rodham Clinton | Islamabad | Met with Prime Minister Gilani, Foreign Minister Khar, and President
Zardari. | October 20–21, 2011 |
| John Forbes Kerry | Islamabad | Met with President Asif Zardari, Prime Minister Nawaz Sharif, National Security
Adviser Sartaj Aziz. Visited Zero Point Power Plant. | July 31–August 2, 2013 |
| John Forbes Kerry | Islamabad | Attended the Second U.S.-Pakistan Strategic Dialogue Ministerial meeting. | January 12–14, 2015 |
| Rex W. Tillerson | Islamabad | Met with senior Pakistani officials. | October 24, 2017 |
| Michael R. Pompeo | Islamabad | Met with Prime Minister Imran Khan, Foreign Minister Qureshi, and Chief of Army
Staff Qamar Javed Bajwa to discuss U.S.-Pakistan bilateral relations. | September 5, 2018 |
