| William Henry Seward | St. Thomas, St. Croix, Frederikstadt, Christianstadt (Virgin Islands) | Met with Danish colonial officials during a working vacation. Also met with former
Mexican President Santa Anna. Departed from Washington January 1. | January 9–12, 1866 |
| Philander Chase Knox | St. Thomas | Met with Danish colonial (Virgin Islands) officials. | March 30, 1912 |
| John Foster Dulles | Copenhagen | Attended NATO Ministerial Meeting. | May 3–8, 1958 |
| William Pierce Rogers | Copenhagen | Attended NATO Ministerial Meeting. | June 12–15, 1973 |
| Henry A. (Heinz Alfred) Kissinger | Copenhagen | Stopped en route to Moscow. | October 23, 1974 |
| Henry A. (Heinz Alfred) Kissinger | Copenhagen | Met with Prime Minister Jorgensen. | January 19–20, 1976 |
| George Pratt Shultz | Copenhagen | Met with Prime Minister Schlueter and Foreign Minister Ellemann-Jensen. | December 12–13, 1987 |
| James Addison Baker | Copenhagen | Met with Foreign Minister Ellemann-Jensen. | February 13, 1989 |
| James Addison Baker | Copenhagen | Attended CSCE Meeting and met with Soviet Foreign Minister Shevardnadze. | June 5–6, 1990 |
| James Addison Baker | Copenhagen | Attended NATO Ministerial Meeting. | June 5–7, 1991 |
| Colin Luther Powell | Copenhagen | Met with Prime Minister Rasmussen and Foreign Minister Moller. | April 29, 2004 |
| Colin Luther Powell | Igaliku | Signed an updated agreement for the defense of Greenland. | August 6, 2004 |
| Condoleezza Rice | Copenhagen | Met with Prime Minister Rasmussen and Foreign Minister Moller. | December 4–5, 2008 |
| Hillary Rodham Clinton | Copenhagen | Attended the UN Climate Change Conference. | December 18–19, 2009 |
| Hillary Rodham Clinton | Nuuk | Attended the Seventh Ministerial Meeting of the Arctic Council. Signed Arctic
Search and Rescue Agreement. | May 11–12, 2011 |
| Hillary Rodham Clinton | Copenhagen | Met with Queen Margrethe II, Prime Minister Helle Thorning-Schmidt, and Foreign
Minister Villy Sovndal. Attended a green partnership for growth event. | May 31–June 1, 2012 |
| John Forbes Kerry | Copenhagen | Met with Prime Minister Lars Lokke Rasmussen and Foreign Minister Kristian
Jensen. | June 16–17, 2016 |
| John Forbes Kerry | Ilulissat | Met with Foreign Minister Vittus Qujaukitsoq and Foreign Minister Jensen. | June 17, 2016 |
| Michael R. Pompeo | Copenhagen | Met with Danish Prime Minister Mette Frederiksen. Also met with Danish Minister of
Foreign Affairs Jeppe Koford, Faroese Minister of Foreign Affairs and Education Jenis av
Rana, and Greenlandic Minister of Foreign Affairs and Energy Steen Lynge. | July 22, 2020 |
| Antony Blinken | Copenhagen | Met with Prime Minister Mette Frederiksen and Foreign Minister Jeppe
Kofod. | May 16–17, 2021 |
| Antony Blinken | Kangerlussuaq | Met with Premier Múte Bourup Egede and Minister Broberg, together with Foreign
Minister Kofod. | May 20, 2021 |
