| Elihu Root | Cartagena | Met with Foreign Minister Vasquez-Cobo. | September 24, 1906 |
| Cordell Hull | Buenaventura | Met with Colombian officials and delivered public addresses. | January 15, 1934 |
| Cordell Hull | Buenaventura | Delivered a public address en route to conference in Lima. | December 2, 1938 |
| Cordell Hull | Buenaventura | Delivered a public address while returning to U.S. | January 1, 1939 |
| George Catlett Marshall | Bogota | Attended Ninth International Conference of American States. | March 30–April 25, 1948 |
| John Foster Dulles | Bogota | Met with President Rojas Pinilla and senior Colombian officials. | July 24–25, 1956 |
| William Pierce Rogers | Bogota | Met with President Pastrana, Foreign Minister Vasquez, and senior Colombian
officials. | May 17–18, 1973 |
| Henry A. (Heinz Alfred) Kissinger | Bogota | Met with President Lopez Michelson and Foreign Minister Lievano Aguirre. | February 22–23, 1976 |
| George Pratt Shultz | Bogota | Accompanied President Reagan on an official working visit. | December 3, 1982 |
| George Pratt Shultz | Cartagena | Attended the opening session of OAS General Assembly. | December 1, 1985 |
| George Pratt Shultz | Bogota | Attended the inauguration of President Barco. | August 6–7, 1986 |
| James Addison Baker | Cartagena | Accompanied President Bush to Drug Summit Meeting with the Presidents of Colombia,
Bolivia, and Peru. | February 15, 1990 |
| James Addison Baker | Bogota | Discussed the Persian Gulf crisis with President Gaviria and Foreign Minister
Jaramillo. | November 24, 1990 |
| Madeleine Korbel Albright | Cartagena | Discussed anti-narcotics assistance with President Pastrana. | January 14–15, 2000 |
| Madeleine Korbel Albright | Cartagena | Accompanied President Clinton. | August 30, 2000 |
| Colin Luther Powell | Bogota | Met with President Uribe and Foreign Minister Barcos. | December 3–4, 2002 |
| Condoleezza Rice | Bogota | Met with President Uribe and Foreign Minister Barco. | April 27–28, 2005 |
| Condoleezza Rice | Bogota | Accompanied President Bush. | March 11, 2007 |
| Condoleezza Rice | Medellin | Led a Congressional delegation to discuss a free-trade agreement and security
issues. | January 24–25, 2008 |
| Hillary Rodham Clinton | Bogota | Met with President Uribe. | June 8–9, 2010 |
| Hillary Rodham Clinton | Cartagena | Attended the 6th Summit of the Americas. | April 13–16, 2012 |
| John Forbes Kerry | Bogota | Met with President Juan Manuel Santos, Foreign Minister Maria Angela Holguin,
Defense Minister Juan Carlos Pinzon, and Colombian Peace Negotiators. | August 12–13, 2013 |
| John Forbes Kerry | Bogota | Met with President Juan Manuel Santos and Foreign Minister Maria Angela
Holguin. | December 12, 2014 |
| John Forbes Kerry | Cartagena | Attended the signing of the Colombian Peace Accord. | September 26, 2016 |
| Rex W. Tillerson | Bogota | Met with President Juan Manuel Santos and Foreign Minister Maria Angela
Holguin. | February 6, 2018 |
| Michael R. Pompeo | Cucuta | Visited entities supporting Venezuelan refugees and assessed the challenges due to
the closed border. | April 14, 2019 |
| Michael R. Pompeo | Bogota | Addressed the Third Western Hemisphere Counterterrorism Ministerial and met with
President Duque and other regional leaders. | January 20, 2020 |
| Michael R. Pompeo | Bogota | Met with Colombian President Ivan Duque. | September 19, 2020 |
| Antony Blinken | Bogota | Met with President Iván Duque and Vice President-Foreign Minister Marta Lucía
Ramírez, co-led a migration ministerial, and opened the U.S.-Colombia High-Level
Dialogue. | October 20–21, 2021 |
| Antony Blinken | Bogota | Met with President Gustavo Petro, Vice President Francia Márquez, and Foreign
Minister Álvaro Leyva. | October 3–4, 2022 |
