| Elihu Root | Lota, Santiago, Valparaiso | Met with President Riesco and Foreign Minister Huneeus; delivered several public
addresses. | August 31–September 4, 1906 |
| Cordell Hull | Santiago, Valparaiso, Antofagasta | Met with President Alessandri, addressed the Senate, and delivered several public
addresses. | January 1–8, 1934 |
| Christian Archibald Herter | Santiago | Attended the 5th Meeting of Consultation of Ministers of Foreign Affairs of the
American States. | August 11–18, 1959 |
| Christian Archibald Herter | Santiago | Accompanied President Eisenhower on a good will tour. | February 29–March 2, 1960 |
| Henry A. (Heinz Alfred) Kissinger | Santiago | Attended OAS General Assembly Meeting. | June 7–9, 1976 |
| Warren Minor Christopher | Santiago | Met with President Frei and Foreign Minister Insulza. | February 27–28, 1996 |
| Madeleine Korbel Albright | Santiago | Accompanied President Clinton on a state visit and to the Second Summit of the
Americas. | April 16–19, 1998 |
| Madeleine Korbel Albright | Santiago | Met with President Lagos and Foreign Minister Alvear. | August 17–18, 2000 |
| Colin Luther Powell | Santiago | Attended OAS General Assembly meeting and met with President Lagos. | June 8–10, 2003 |
| Colin Luther Powell | Santiago | Attended APEC Ministerial meetings and accompanied President Bush to the APEC
Summit meeting. | November 17–21, 2004 |
| Condoleezza Rice | Santiago | Attended the Communities of Democracies Ministerial Meeting. | April 28–29, 2005 |
| Condoleezza Rice | Valparaiso, Santiago, Vina de Lar | Attended the inauguration of President Bachelet. | March 10–12, 2006 |
| Condoleezza Rice | Santiago | Met with President Bachelet and Foreign Minister Foxley. | March 14–15, 2008 |
| Hillary Rodham Clinton | Santiago | Met with President Bachelet and President-elect Pinera. Discussed disaster
relief. | March 2, 2010 |
| John Forbes Kerry | Valparaiso | Attended the second Our Ocean Conference. | October 5, 2015 |
| Michael R. Pompeo | Santiago | Met with President Piñera and Foreign Minister Ampuero. | April 12, 2019 |
| Antony Blinken | Santiago | Met with President Gabriel Boric and Foreign Minister Antonia Urrejola. | October 5, 2022 |
